https://www.researchsquare.com/article/rs-1749502/v1
"First infection with SARS-CoV-2 is associated with increased risk of acute and
post-acute death and sequelae in the pulmonary and extrapulmonary organ
systems. However, whether reinfection adds to the risk incurred after the first
infection is not clear. Here we use the national health care databases of the
US Department of Veterans Affairs to build a cohort of people with first
infection (n = 257,427), reinfection (2 or more infections, n = 38,926), and a
non-infected control group (n = 5,396,855) to estimate risks and 6-month
burdens of all-cause mortality, hospitalization, and a set of pre-specified
incident outcomes.
We show that compared to people with first infection, reinfection contributes
additional risks of all-cause mortality, hospitalization, and adverse health
outcomes in the pulmonary and several extrapulmonary organ systems
(cardiovascular disorders, coagulation and hematologic disorders, diabetes,
fatigue, gastrointestinal disorders, kidney disorders, mental health disorders,
musculoskeletal disorders, and neurologic disorders); the risks were evident in
those who were unvaccinated, had 1 shot, or 2 or more shots prior to the second
infection; the risks were most pronounced in the acute phase, but persisted in
the post-acute phase of reinfection, and most were still evident at 6 months
after reinfection.
Compared to non-infected controls, assessment of the cumulative risks of
repeated infection showed that the risk and burden increased in a graded
fashion according to the number of infections. The constellation of findings
show that reinfection adds non-trivial risks of all-cause mortality,
hospitalization, and adverse health outcomes in the acute and post-acute phase
of the reinfection. Reducing overall burden of death and disease due to
SARS-CoV-2 will require strategies for reinfection prevention."
Via Kee Hinckley and Muse.
Cheers,
*** Xanni ***
--
mailto:xanni@xanadu.net Andrew Pam
http://xanadu.com.au/ Chief Scientist, Xanadu
https://glasswings.com.au/ Partner, Glass Wings
https://sericyb.com.au/ Manager, Serious Cybernetics
