"If you have ever taken a medicine, then you have benefited from research in
animals. But ten years ago, if you looked at a scientific report involving mice
or rats, it would probably have used only male animals.
This means that, even now, if you’re a woman and the medicine has only been
developed and tested using male animals, we don’t know how that medicine is
going to affect you.
Scientists long assumed that females would respond the same way as males in
drug trials. But today, that situation is changing. More and more studies use
both female and male animals – and new science is emerging about important sex
differences as a result.
For example, a growing body of evidence from animal studies is highlighting
complex sex differences in rodent brains, relating to their size, shape, and
how nerve cells connect with one another.
So it’s no surprise that research is also increasingly showing sex differences
in human medical issues. For example, women are twice as likely as men to be
diagnosed with depression, and sex differences are also clear in people’s
response to antidepressants. Women have a stronger response than men to
selective serotonin reuptake inhibitors (SSRIs), whereas men have a better
response to tricyclic antidepressants."
*** Xanni ***
Chief Scientist, Xanadu
Partner, Glass Wings
Manager, Serious Cybernetics