<
https://theconversation.com/advantages-and-challenges-of-anti-covid-nasal-vaccination-the-promises-of-a-french-approach-197746>
"Contrary to the widely shared popular belief, the primary purpose of current
vaccines against Covid-19 is solely to protect against serious forms of the
disease in order to prevent the risk of hospitalisations and death… and not to
block transmission between individuals. To do this, it would be necessary to
aim for a so-called sterilising vaccination: only then could the circle of
contamination be interrupted, allowing to stop the pandemic.
How to reach this level of efficacy? In general, vaccination allows the
induction of an immune response based on two types of cells: T lymphocytes,
capable of destroying infected cells, and B lymphocytes which produce
antibodies capable of neutralising the virus (SARS-CoV-2 in the case of Covid)
to prevent it from multiplicating and infecting new healthy cells.
Current vaccines (including mRNA) are administered intramuscularly and are so
called “systemic”: they allow the activation at the level of the whole body of
a pool of immune cells, circulating by the blood, which can further reach the
infected organs.
Effective as it is, this systemic immunity does not allow the mobilisation of a
high level of B and T lymphocytes in the nasal cavity and the lungs – to
promote a rapid and effective protection against the virus – blocking it as
soon as it arrives.
Conversely, an intranasal vaccination induces not only a systemic but also a
local immune response – directly, therefore, at the gate of the entry of
SARS-CoV-2. The local activation of the immune cells of the nasal mucosa would
thus make it possible to overcome the race against time between the virus
(which multiplies in our respiratory system) and our systemic immune system
(which need to be mobilised to the infected site). Concretely this mucosal
vaccination would quickly stop the virus and block its possibilities of
dissemination and replication in our organism and thus avoid transmission and
contamination."
Cheers,
*** Xanni ***
--
mailto:xanni@xanadu.net Andrew Pam
http://xanadu.com.au/ Chief Scientist, Xanadu
https://glasswings.com.au/ Partner, Glass Wings
https://sericyb.com.au/ Manager, Serious Cybernetics
