Risk of long COVID in children may be twice as high after a second infection

Fri, 3 Oct 2025 18:21:20 +1000

Andrew Pam <xanni [at] glasswings.com.au>

Andrew Pam
<https://medicalxpress.com/news/2025-09-covid-children-high-infection.html>

"A new study published in The Lancet Infectious Diseases involving over
460,000 children and adolescents across 40 pediatric hospitals in the U.S.
suggests that children who were infected with COVID-19 for the second time
during the omicron wave had more than double the risk of developing long COVID.

Conducted by researchers under the RECOVER Initiative, this is the largest
study to date examining the long-term effects of COVID-19 reinfection in young
people.

The study analyzed electronic health records from January 2022 through October
2023, a period dominated by the highly transmissible omicron variant.
Researchers compared health outcomes following children's first and second
documented COVID-19 infections to isolate the risks associated with
reinfection.

They found that after the first COVID-19 infection, about 904 children per
million developed long COVID within six months. Following a second infection
(reinfection), this number more than doubled to approximately 1,884 children
per million.

The higher risk was observed across many different groups in the study,
regardless of whether they were vaccinated, how serious their first illness
was, their age, gender, race or ethnicity, or if they were living with
overweight or obesity.

The authors say this increased risk of long COVID following reinfections
highlights the continued importance of preventing COVID-19 infections through
vaccination and other protective measures such as masking and social
distancing.

Reinfection was linked to a wide range of rare but persistent and sometimes
serious conditions potentially associated with long COVID in children,
including heart inflammation (myocarditis), blood clots, kidney injury,
cognitive difficulties, fatigue, and respiratory problems.

The authors emphasize that while vaccines and other prevention measures may not
completely eliminate the risk of contracting COVID-19, they remain the most
effective way to prevent both initial infections and reinfections, thereby
reducing the risk of long-lasting symptoms in children."

Via Violet Blue’s Threat Model - Covid: October 2, 2025
https://www.patreon.com/posts/covid-october-2-140250567

Cheers,
       *** Xanni ***
--
mailto:xanni@xanadu.net               Andrew Pam
http://xanadu.com.au/                 Chief Scientist, Xanadu
https://glasswings.com.au/            Partner, Glass Wings
https://sericyb.com.au/               Manager, Serious Cybernetics

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